Endocrine Abstracts

Two members of the melanocortin (MC) receptor family are abundantly expressed in the adrenal cortex, namely MC2R and MC5R. MC2R binds only ACTH and is known as the ACTH receptor, the role of MC5R however is still under investigation. It is known that alpha-MSH stimulates aldosterone secretion by the rat adrenal cortex, by an MC2R-independent mechanism, although the receptor involved has not been identified. The experiments were designed to investigate the role of MC5R in the a...